Fasudil相关论文
耳聋的发病率居全球感觉器官致残性疾病的首位,分为传导性听力损失和感音神经性听力损失。耳毒性药物中氨基糖苷类抗生素最为常见,......
Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195
OBJECTIVE In this study,we used a new cationic peptide H3R5 as a reducible vector,aptamer ST21 with specific binding to ......
目的 以体外培养的新生大鼠神经元为研究对象,观察缺氧损伤后神经细胞RhoA、ROCK-Ⅰ、ROCK-Ⅱ蛋白表达情况以及神经元突起长度、神......
Background: Percutaneous carotid artery stenting in the prevention of cerebral vascular diseases are increasingly concer......
Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced b
Tobacco smoking, a widely spread habit, has been found associated with declined cognitive functions.Fasudil, an inhibito......
Fasudil is a selective and potent RhoA/Rho kinase (ROCK) inhibitor and vasodilator.Since it was discovered, it has been ......
The Impact of Rho kinase inhibition on cardiac and plasma Angiotensin (1-7) in pressure-overload Rat
Objective: Inhibition of Rho-kinase displays property against cardiac remodeling, although its effect on has not been fu......
Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell pr
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Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with typ
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目的观察法舒地尔联合阿替普酶(rt-PA)静脉溶栓治疗急性脑梗死(ACI)的效果。方法回顾性分析商丘市立医院2018年9月至2020年2月收治......
Preliminary investigation of safety and efficacy of fasudil in subjects with amyotrophic lateral scl
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目的探讨法舒地尔(Fasudil)在小鼠脑缺血再灌注(Ischemia/reperfusion，I/R)损伤中的神经保护作用。方法51只C57BL/6J小鼠随机分为两......
Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better tha
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The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral is
The Rho/Rho-kinase signaling pathway plays an important role in cerebral ischemia/reperfusion injury. However, very few ......
目的探讨法舒地尔联合脑苷肌肽治疗2型糖尿病并耳鸣耳聋的临床疗效。方法选取2016年1－12月大同市第五人民医院收治的2型糖尿病并耳......
目的 观察血液净化联合法舒地尔治疗老年心脏术后急性肾损伤的临床效果.方法 50例老年心脏术后急性肾损伤患者,按随机数字表法分为......
目的：探讨对脑血管痉挛患者采用法舒地尔治疗的临床效果与安全性。方法选取漯河市第二人民医院2013年2月至2014年2月收治的脑血管痉......
目的 探讨法舒地尔对急性脑梗死患者血清超敏C反应蛋白(hs-CRP)和淀粉样蛋白A(SAA)的影响.方法 100例急性脑梗死患者数字表法随机......
目的研究法舒地尔治疗老年人舒张性左心衰竭相关性肺动脉高压的有效性和安全性,为临床治疗提供依据。方法选取老年舒张性左心衰竭......
目的观察法舒地尔对急性心肌梗死患者择期冠状动脉支架植入术后即刻心肌呈色分级的影响。方法急性心肌梗死患者92例,随机分为治疗......
RhoA与其下游的效应物ROCK相互作用,调控肺血管收缩、肺血管重构、血栓形成以及炎症反应等病理生理过程,参与肺动脉高压的形成与发......
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目的探讨Fasudil(法舒地尔)介导的细胞治疗对实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis, EAE)巨噬细......
前期研究发现,急性癫痫发作后小鼠皮层神经元树突水肿、棘突减少,并伴随肌动蛋白解聚因子cofilin磷酸化水平下降。cofilin是Rho/Rh......
目的 探讨Rho/Rho激酶抑制剂法舒地尔联合常规血管扩张剂硝酸甘油治疗不稳定型心绞痛的效果.方法 选择20例不稳定型心绞痛(左冠状......
目的 通过临床观察评价法舒地尔注射液治疗蛛网膜下腔出血(SAH)后迟发脑血管痉挛(DCVS)的疗效. 方法 以尼莫地平为对照,用随机分组......
Fasudil hydrochloride系脑血管挛缩治疗药,为异喹啉磺酰胺衍生物。本品不降低细胞内钙浓度,可抑制细胞内钙依赖性血管收缩。动物......
目的比较WAR-5与盐酸法舒地尔(Fasudil)对实验性自身免疫性脑脊髓炎(EAE)的治疗效果,并探究其作用机制。方法采用小鼠髓鞘少突胶质......
目的探讨法舒地尔(Fasudil)对体外培养骨髓源神经干细胞(BMNSC)增殖和存活的影响。方法取3~4周龄的C57BL/6小鼠,分离骨髓基质细胞......
Environmental enrichment combined with fasudil promotes motor function recovery and axonal regenerat
Fasudil, a Rho-associated protein kinase (ROCK) inhibitor, has a protective effect on the central nervous system. In add......
目的研究对比法舒地尔不同给药途径治疗颅内动脉瘤栓塞后脑血管痉挛的临床效果,为临床医生治疗颅内动脉瘤栓塞后脑血管痉挛提供可......
Maxingxiongting mixture attenuates hypoxia pulmonary arterial hypertension to improve right ventricu
OBJECTIVE: To explore the mechanism of Maxingxiongting mixture (MXXTM) on pulmonary hypertension in a rat model establis......
目的:新结构Rho激酶抑制剂DL0805-2是前期发现的抗高血压急症候选药物,实验拟观察DL0805-2对心血管系统、呼吸系统和中枢神经系统......
目的探讨曲美他嗪联合法舒地尔治疗慢性心力衰竭(CHF)的疗效和可能作用机制。方法 CHF患者88例,随机分为两组。对照组43例,采用常......
Clinical study on low-frequency repetitive transcranial magnetic atimulation combined with fasudil i
Objective: To investigate the effect of low-frequency rTMS combined with fasudil on neurological function in patients wi......
目的探讨法舒地尔治疗先天性心脏病相关性重度肺动脉高压短期应用的有效性及安全性。方法入选2011年1月~2012年8月我科住院的先天......
目的探讨盐酸法舒地尔对冠状动脉慢血流(coronary slow flow,CSF)患者的治疗作用及对血浆中机体氧化应激指标丙二醛(MDA)、晚期糖......
目的观察法舒地尔对冠心病并牙周炎患者血清及龈沟液中炎性因子白介素(IL)-10,IL-18的影响。方法住院的冠心病伴牙周炎的患者,随机......
目的建立博来霉素诱导小鼠肺纤维化模型，观察ROCK抑制剂法舒地尔对肺纤维化的干预作用；同时体外培养NIH3T3成纤维细胞，观察法舒地尔对......
,Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmu
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,Blocking VEGF/Caveolin-1 signaling contributes to renal protection of fasudil in streptozotocin-ind
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目的:Rho/Rho激酶(Rock)信号途径是机体中普遍存在的信号转导通路,参与调控细胞的增殖、粘附、移行等,被认为是控制细胞行为的上游......
目的观察盐酸法舒地尔干预治疗急性心肌梗死(AMI)患者的血液流变学和血清炎性细胞因子的变化,探讨盐酸法舒地尔在AMI中可能的作用......
The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal c
Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central ......
目的 观察法舒地尔对矽肺大鼠肌成纤维细胞分化的调节作用.方法 采用非暴露式支气管灌注二氧化硅构建矽肺大鼠模型(模型组),并予以......
A Rho-kinase Inhibitor, Fasudil, Attenuates Progressive Glomerulosclerosis Induced by Daunorubicin i
Accumulating evidence suggests that the small G protein Rho and its downstream effector Rho kinase may play important ro......
目的探讨法舒地尔对慢性肾衰竭小鼠肌肉萎缩的抑制作用。方法采用数字表法将20只小鼠随机分为正常对照组(CTL组)、法舒地尔组(F组)......
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Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell pr
Background RhoA/ Rho kinase (ROCK) pathway is involved in pulmonary arterial hypertension (PAH) and pulmonary artery smo......
